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What is Visco-3?

Visco-3 is a hyaluronan preparation that is injected into a knee joint, in a procedure generally called viscosupplementation. Hyaluronan is a natural substance present in the joint fluid that assists in lubrication to allow smooth movement of the cartilage-covered articulating surfaces of the joint.


Visco-3 is indicated in the management of knee osteoarthritis that has not responded to non-surgical treatment options such as pain medications, physical therapy, and exercise.

Viscosupplementation injections provide symptomatic relief and delay the need for surgery. They are injected directly into the joint to replenish the diminished synovial fluid, thereby enhancing its lubricating properties. A single dose or a total of 3separate doses over several weeks may be required for optimum benefit.


The procedure first involves the removal of any excess joint fluid with a syringe. Visco-3 is then injected into the affected knee joint directly. These injections not only supplement the hyaluronan in the joint but also stimulate the production of hyaluronan in the treated knee, providing gradual symptomatic relief over the course of the injections. The effect can last for several months.

Risks and Complications

Some patients may experience mild pain, swelling, warmth, and redness at the injection site for up to 48 hours following a Viscosupplementation injection. Headache and joint stiffness may also occur in some cases. Ice packs and analgesics (pain-relievers) may be used to ease any discomfort. Strenuous activity such as jogging or tennis should be completely avoided for 48 hours to a week after the injection and should be resumed only after consultation with your doctor.

Immediately consult your doctor if you develop:

  • Back pain
  • Fever
  • Tingling skin
  • Headache
  • Serious allergic reaction, including rash, itching/swelling especially of the face, tongue or throat
  • Severe dizziness
  • Breathing difficulty

Related Topics

  • Columbia University Department of Rehabilitation and Regenerative Medicine
  • American Academy of Physical Medicine and Rehabilitation
  • American Society of Regional Anesthesia and Pain Medicine
  • NewYork–Presbyterian Hospital
  • University of Michigan
  • Association of Academic Physiatrists